Prince Robert of Luxembourg has revealed the untimely death of Prince Frederik, his youngest son, who was 22 years old.
According to the cousin of Henri, Grand Duke of Luxembourg, whose unexpected abdication last year put an end to a magnificent 24-year reign, his son passed away on March 1 after a protracted fight with POLG Mitochondrial Disease, a rare genetic disorder.
n a long, poignant comment, he expressed his sorrow over the news on the POLG foundation, a website his son started that is devoted to discovering a cure and efficient therapies for mitochondrial illnesses caused by POLG.
According to the foundation, POLG sickness is a rare genetic condition that deprives the body’s cells of energy, leading to gradual failure and dysfunction of many organs.
In addition to the intestines, muscles, and swallowing abilities, the disorder can progress to the point where several organs, including the liver and brain, fail.

Prince Frederik, who had a lifelong illness diagnosed at 14, tragically passed away on Rare Disease Day, February 28. His parents, Prince Robert and Princess Julie of Nassau, shared a heartfelt message about his final moments. Frederik, the founder of the POLG Foundation, bid farewell to his family, showing immense strength and humor. Despite his battle with a rare disease, he remained positive, often making others laugh. He also helped establish the foundation to support research and raise awareness. Known for his compassion, emotional intelligence, and sense of justice, Frederik left a lasting impact on his family and others.